4727.0.55.002 - Australian Aboriginal and Torres Strait Islander Health Survey: Users' Guide, 2012-13  
ARCHIVED ISSUE Released at 11:30 AM (CANBERRA TIME) 10/09/2014  First Issue
   Page tools: Print Print Page Print all pages in this productPrint All  



Apolipoprotein B (Apo B) is primarily the protein component of Low Density Lipoprotein (LDL) cholesterol. Evidence from research suggests that Apo B is the superior indicator of cardiovascular disease (CVD) risk as there is only one Apo B protein found on each LDL particle and it can be measured directly (as opposed to using an equation to determine LDL cholesterol levels).1 High levels of Apo B may increase the risk of CVD.

The Apo B test measures the amount of Apo B circulating in the blood at the time of the test.


Apo B results were obtained for selected persons aged 18 years and over, who agreed to participate in the National Aboriginal and Torres Strait Islander Health Measures Survey (NATSIHMS) and who provided a blood sample. Fasting was not required for this test.


A blood sample was collected from participants and Apo B levels were measured at the Douglass Hanly Moir (DHM) laboratory.

There is no consensus on the cut off reference values for defining abnormal Apo B, as there are currently a number of different methods that can be used to measure Apo B. As such, laboratory reference ranges, which are based on major clinical trials, have been used in the NATSIHMS. In the NATSIHMS, cut off reference values for normal and abnormal results were sourced from DHM laboratory reference ranges.2

In the NATSIHMS, the following definitions were used for serum Apo B:

Cut off points for Apo B in the NATSIHMS

Apo B levels for females
Apo B levels for males


Further test information about the analysis method and machine used to measure Apo B levels is available in Excel spreadsheet format in the Downloads page of this product.

Data items

The data items and related output categories for this topic are available in Excel spreadsheet format from the Downloads page of this product.


Points to be considered when interpreting data for this topic include the following:
  • Apo B results do not confirm a specific diagnosis without consultation with a health professional.
  • Age, gender and taking lipid lowering medications are all variables that may affect lipid and lipoprotein levels.3 As a result, the data should be interpreted with care.
  • There are a number of different test methods for measuring Apo B, which may produce different results. The data from this topic should therefore be used with caution when comparing Apo B results from other studies using a different test method or equation.
  • According to the lipid guidelines, Apo B results may be used in place of LDL cholesterol results to report the prevalence of CVD, especially when LDL cholesterol results are not reported, as a result of a person's triglyceride level being ≥ 4.5 mmol/L.4 According to Friedewald et al (1972), the inclusion of triglyceride levels ≥ 4.5 mmol/L (400 mg/100 ml) will result in the generation of a false LDL cholesterol result.5
  • The Apo B normal and abnormal cut off points are based on DHM laboratory reference ranges. These ranges may vary depending on the analytical method and analytical machine, as there is currently no standard method or epidemiological guidelines to report normal and abnormal cut off points for Apo B.
  • In the NATSIHMS an upper limit cut off has been reported to differentiate between normal and abnormal Apo B levels.

Comparability with other surveys

The NATSIHMS is the first ABS Aboriginal and Torres Strait Islander survey to collect biomedical information. Given it was also the first national level survey (ABS or otherwise) to collect such data for the Aboriginal and Torres Strait Islander population, no comparisons with previous surveys for this population are possible.

However, biomedical data was also collected for all Australians in the 2011-12 National Health Measures Survey (NHMS) and information about comparisons between the NHMS results and those of non-ABS surveys is available from the Comparisons with other Australian surveys section of the Biomedical Results for Chronic Diseases, 2011-12 publication.


1 Barter PJ, Ballantyne CM, Carmena R, Castro Cabezas M, Chapman MJ, Couture P, de Graaf J, Durrington PN, Faergeman O, Frohlich J, Furberg CD, Gagne C, Haffner SM, Humphries SE, Jungner I, Krauss RM, Kwiterovich P, Marcovina S, Packard CJ, Pearson TA, Reddy KS, Rosenson R, Sarrafzadegan N, Sniderman AD, Stalenhoef AF, Stein E, Talmud PJ, Tonkin AM, Walldius G, Williams KM, 2006, Apo B versus cholesterol in estimating cardiovascular risk and in guiding therapy: report of the thirty-person/ten-country panel, Heart Research Institute, Journal of Internal Medicine, <http://www.ncbi.nlm.nih.gov/pubmed/16476102>, Last accessed 08/09/2014.
2 Heil W, Ehrhardt V, 2008, Reference Ranges for Adults and Children: Pre-Analytical Considerations, Roche Diagnostics GmbH, Mannheim, <https://www.rochediagnostics.fr/Htdocs/media/pdf/actualites/2a_Reference_Ranges_2008.pdf>, Last accessed 08/09/2014.
3 Appleton CA, Caldwell G, McNeil A, Meerkin M, Sikaris K, Sullivan DR, Thomas DW, and DP Tognarini, Australian Pathology Lipid Interest Group, 2007, Recommendations for Lipid Testing and Reporting by Australian Pathology Laboratories, <http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1904423/>, Last accessed 08/09/2014.
4 National Heart Foundation of Australia and the Cardiac Society of Australia and New Zealand, 2005, Position Statement on Lipid Management - 2005, <http://www.heartfoundation.org.au/sitecollectiondocuments/the-lipid-position-statement.pdf>, Last accessed 08/09/2014.
5 Friedewald WT, Levy RI, Fredrickson DS,1972, Estimation of the low-density lipoprotein cholesterol in plasma without use of preparative ultracentrifuge, <http://www.clinchem.org/content/18/6/499.full.pdf>, Last accessed 08/09/2014.

Previous PageNext Page