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LOW DENSITY LIPOPROTEIN (LDL) CHOLESTEROL
LDL cholesterol (mmol/L) = Total cholesterol – HDL cholesterol - Triglyceride/2.2
In the NHMS, cut off reference values for normal and abnormal results were sourced from the 2005 position statement2 on lipid management by the National Heart Foundation Australia and the Cardiac Society of Australia and New Zealand (NHFA/CSANZ). These guidelines are based on epidemiological data and publications of major clinical trials.
In the NHMS, the following definitions were used for LDL cholesterol:
Further test information about the analysis method and machine used to measure lipid levels is available in Excel spreadsheet format in the Downloads page of this product.
The data items and related output categories for this topic are available in Excel spreadsheet format from the Downloads page of this product.
Points to be considered when interpreting data for this topic include the following:
Comparability with other surveys
The NHMS is the first ABS survey to collect biomedical data on cholesterol levels.
Cholesterol data has been collected in other non-ABS surveys. However, caution must be taken when interpreting results due to the differences in scope, assay and instrument, and any thresholds applied in the final analysis. Further information about these comparisons is available from the Comparisons with other Australian surveys section of the Biomedical Results for Chronic Diseases, 2011-12 publication.
1 National Heart Foundation of Australia, 2013, Cholesterol, <http://www.heartfoundation.org.au/SiteCollectionDocuments/NAHU-Cholesterol.pdf>, Last accessed 08/07/2013.
2 National Heart Foundation of Australia and the Cardiac Society of Australia and New Zealand, 2005, Position Statement on Lipid Management - 2005, <http://www.heartfoundation.org.au/sitecollectiondocuments/the-lipid-position-statement.pdf>, Last accessed 22/10/2013.
3 Friedewald WT, Levy RI, Fredrickson DS,1972, Estimation of the low-density lipoprotein cholesterol in plasma without use of preparative ultracentrifuge, <http://www.clinchem.org/content/18/6/499.full.pdf>, Last accessed 22/10/2013.
4 Appleton CA, Caldwell G, McNeil A, Meerkin M, Sikaris K, Sullivan DR, Thomas DW, and DP Tognarini, Australian Pathology Lipid Interest Group, 2007, Recommendations for Lipid Testing and Reporting by Australian Pathology Laboratories, <http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1904423/>, Last accessed 22/10/2013.